The Perineural Invasion Paradox: Is Perineural Invasion an Independent Prognostic Indicator of Biochemical Recurrence Risk in Patients With pT2N0R0 Prostate Cancer? A Multi-Institutional Study
نویسندگان
چکیده
منابع مشابه
Perineural Invasion and Risk of Lethal Prostate Cancer.
Background: Prostate cancer has a propensity to invade and grow along nerves, a phenomenon called perineural invasion (PNI). Recent studies suggest that the presence of PNI in prostate cancer has been associated with cancer aggressiveness.Methods: We investigated the association between PNI and lethal prostate cancer in untreated and treated prostate cancer cohorts: the Swedish Watchful Waiting...
متن کامل[Prognostic role of perineural invasion in prostate biopsy].
INTRODUCTION Despite tumour cell dissemination through the intraprostatic nervous system being considered as a prostate cancer progression mechanism, the significance of perineural invasion in prostate biopsies to predict extraprostatic extension and its use as a potential prognosis factor is controversial. MATERIALS AND METHODS Retrospective study carried out at an institution on 208 patient...
متن کاملPrediction of Perineural Invasion and Its Prognostic Value in Patients with Prostate Cancer
PURPOSE The prognostic significance of perineural invasion by prostate cancer is debated. We investigated the association between perineural invasion and clinicopathological factors and the effect of perineural invasion on survival in patients with prostate cancer. MATERIALS AND METHODS A total of 361 patients with prostate cancer without any neoadjuvant therapies prior to surgery from 1999 t...
متن کاملPrognostic significance of perineural invasion in patients who underwent radical prostatectomy for localized prostate cancer.
PURPOSE Perineural space invasion (PNI) is an important mechanism for progression of cancer through the prostatic capsule, the prognostic significance of PNI remains controversial. The purpose of the present study was to assess the prognostic significance of PNI between prostate biopsy and radical prostatectomy (RP) samples of patients affected by clinically localized prostate cancer (PCa). M...
متن کاملPredicting the risk of non-organ-confined prostate cancer when perineural invasion is found on biopsy.
OBJECTIVE To more precisely define the risk of non-organ-confined (non-OC) prostate cancer among men with perineural invasion (PNI) identified on prostate biopsy. MATERIALS AND METHODS The Johns Hopkins radical prostatectomy database was queried for men with PNI reported on prostate biopsy. Patients with and without non-OC disease were compared for differences in preoperative clinical and pat...
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ژورنال
عنوان ژورنال: Advances in Radiation Oncology
سال: 2019
ISSN: 2452-1094
DOI: 10.1016/j.adro.2018.09.006